Alireza Monazzami scored the only goal of the match in the 43rd minute in Isfahan’s Fooladshahr Stadium.
Zob Ahan jumped up to 12th in the IPL table with the victory and Foolad remained in 7th place.
Earlier in the day, Saipa and rock-bottom Shahin Bushehr played out a goalless draw.
Shahr Khodro sits top of the table with 23 points, one point ahead of Sepahan.