The overcrowded camp packed with desperate refugees and migrants has become a potent symbol of the human suffering and chaos as Europe struggles to cope with its worst migrant crisis since World War II.
In an operation which began shortly after sunrise, hundreds of Greek police began evacuating the sprawling camp which is currently home to 8,400 refugees and migrants, among them many families with children, AFP reported.
At its height, there were more than 12,000 people crammed into the site, many of them fleeing war, persecution and poverty, with the camp exploding in size since Balkan states began closing their borders in mid-February in a bid to stem the human tide seeking passage to northern Europe.
A helicopter hovered overhead as the operation got under way, with police sources saying at least 700 officers were involved in the evacuation which aims to clear the camp and take the people to reception centers and camps dotted around the country.
The move comes after a brutal winter of freezing rain and mud which saw many people trying to force their way across the border, sometimes resulting in a violent standoff with the Macedonian police.
But officials said Tuesday's operation was proceeding calmly in the flashpoint camp, which has often been the scene of angry confrontations with the security forces.
"The operation began Tuesday around 0400 GMT and is taking place slowly and in a calm atmosphere. There has not been any need to use force," Yiorgos Kyritsis, the government's migration spokesman, told AFP.