A total of 6,021 migrants and refugees have made the dangerous sea crossing since Tuesday, IOM spokesman Joel Millman said, adding that all landed in Italy, excluding 174 people who reached Greece.
Millman stressed that there was no evidence yet to suggest the rise in Italy arrivals was linked to an EU-Turkey deal aimed at stemming the influx of people to Europe via the Greek islands, or the closure of the Balkans migrant route.
Migrants who spoke to IOM staff in Italy all said they had crossed from Libya, according to AFP.
Most traveled on rubber dinghies, with roughly 130 people packed on each, the IOM said in a statement.
"Many of them were from sub-Saharan Africa, and we have noticed an increase in numbers from the Horn of Africa, particularly Eritreans," Federico Soda, head of the IOM's Rome office, said in the statement.
"There have been very few Syrians leaving from Libya in recent months," Soda further said.
Millman noted that with weather warming at the start of the main crossing season, Italy would likely see persistently high arrivals in the weeks ahead.
So far this year, more than 23,000 migrants have landed in Italy, compared to nearly 153,500 who have landed in Greece, the IOM said.